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Article

Cyclodipeptide Synthases of the NYH Subfamily Recognize tRNA Using an α-Helix Enriched with Positive Residues.

Biochemistry - 12 Jan 2021

Croitoru Anastasia, Babin Morgan, Myllykallio Hannu, Gondry Muriel, Aleksandrov Alexey

Abstract excerpt

Cyclodipeptide synthases (CDPSs) perform nonribosomal protein synthesis using two aminoacyl-tRNA substrates to produce cyclodipeptides. At present, there are no structural details of the CDPS:tRNA interaction available. Using AlbC, a CDPS that produces cyclo(l-Phe-l-Phe), the interaction between AlbC and its Phe-tRNA substrate was investigated. Simulations of models of the AlbC:tRNA complex, proposed by...

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PMID: 33331769
DOI: 10.1021/acs.biochem.0c00761

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