Article
Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T cells and correlation with the PD-1.3A genotype in patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Jun 2010
Kristjansdottir Helga, Steinsson Kristjan, Gunnarsson Iva, Gröndal Gerdur, Erlendsson Kristjan, Alarcón-Riquelme Marta E
Abstract excerpt
OBJECTIVE: A genetic polymorphism in the programmed death 1 (PD-1) gene encoding the coinhibitory PD-1 immunoreceptor, PD-1.3A, is associated with systemic lupus erythematosus (SLE). The aim of this study was to assess PD-1 receptor expression in patients with SLE, in comparison with relatives and unrelated healthy controls, and to identify correlations of lower expression levels of PD-1 receptor with the PD-1.3A...
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