A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.

doi:10.1038/ng1020

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Article

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.

Nature genetics - 1 Dec 2002

Prokunina Ludmila, Castillejo-López Casimiro, Oberg Fredrik, Gunnarsson Iva, Berg Louise, Magnusson Veronica, Brookes Anthony J, Tentler Dmitry, Kristjansdóttir Helga, Gröndal Gerdur, Bolstad Anne Isine, Svenungsson Elisabet, Lundberg Ingrid, Sturfelt Gunnar, Jönssen Andreas, Truedsson Lennart, Lima Guadalupe, Alcocer-Varela Jorge, Jonsson Roland, Gyllensten Ulf B, Harley John B, Alarcón-Segovia Donato, Steinsson Kristján, Alarcón-Riquelme Marta E

Abstract excerpt

Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women. A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified. We previously reported a susceptibility locus (SLEB2) for Nordic multi-case families. Within this...

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Identifiers

PMID: 12402038
DOI: 10.1038/ng1020

Genes

PDCD1
RUNX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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