Article
Association of programmed cell death-1 (PDCD-1) gene polymorphisms with rheumatoid arthritis in Iranian patients.
Clinical and experimental rheumatology - 1 Jan 2000
Tahoori Mohammad Taher, Pourfathollah Ali Akbar, Akhlaghi Masoomeh, Daneshmandi Saeed, Nicknam Mohammad Hosein, Soleimanifar Narjes
Abstract excerpt
OBJECTIVES: Programmed cell death 1 (PDCD-1, also named PD-1, CD279, and SLEB2), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (RA). Herein, we investigate the association of PDCD-1 polymorphisms with the risk of RA among...
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