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Article

A change in the conformation of prions accompanies the emergence of a new prion strain.

Neuron - 13 Jun 2002

Peretz David, Williamson R Anthony, Legname Giuseppe, Matsunaga Yoichi, Vergara Julie, Burton Dennis R, DeArmond Stephen J, Prusiner Stanley B, Scott Michael R

Abstract excerpt

To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubation times, diagnostic of a species barrier. PrP(Sc) of the new MH2M(Sc237) strain possessed...

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Identifiers

PMID: 12086640
DOI: 10.1016/s0896-6273(02)00726-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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