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Article

Experimental verification of a traceback phenomenon in prion infection.

Journal of virology - 1 Apr 2010

Kobayashi Atsushi, Sakuma Nobuyuki, Matsuura Yuichi, Mohri Shirou, Aguzzi Adriano, Kitamoto Tetsuyuki

Abstract excerpt

The clinicopathological phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD) correlate with the allelotypes (M or V) of the polymorphic codon 129 of the human prion protein (PrP) gene and the electrophoretic mobility patterns of abnormal prion protein (PrP(Sc)). Transmission of sCJD prions to mice expressing human PrP with a heterologous genotype (referred to as cross-sequence transmission) results in...

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Identifiers

PMID: 20089646
DOI: 10.1128/JVI.02387-09
PMCID: PMC2838106

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