Article
Molecular pathogenesis of human hepatocellular carcinoma.
Toxicology - 27 Dec 2002
Wang Xin W, Hussain S Perwez, Huo Teh-Ia, Wu Chuan-Ging, Forgues Marshonna, Hofseth Lorne J, Brechot Christian, Harris Curtis C
Abstract excerpt
Primary hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. However, the viral-chemical etiology as well as molecular mechanisms of HCC pathogenesis remains largely unknown. Recent studies in our laboratory have identified several potential factors that may contribute to the pathogenesis of HCC. Oxidative stress and chronic inflammation have been linked to an increased risk of liver...
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