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Article

Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain.

Journal of bacteriology - 1 Apr 2010

Hwang Jihwan, Inouye Masayori

Abstract excerpt

Der, an essential Escherichia coli tandem GTPase, has been implicated in 50S subunit biogenesis. The rrmJ gene encodes a methyltransferase that modifies the U2552 residue of 23S rRNA, and its deletion causes a severe growth defect. Peculiarly, overexpression of Der suppresses growth impairment. In this study, using an rrmJ-deletion strain, we demonstrated that two GTPase domains of Der regulate its association...

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Identifiers

PMID: 20172997
DOI: 10.1128/JB.00045-10
PMCID: PMC2849445

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Related research

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Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain.PMID 20172997Read ↗

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Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly.Semantic proximity Read ↗

Overexpression of two different GTPases rescues a null mutation in a heat-induced rRNA methyltransferase.Semantic proximity Read ↗

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