Article
Functional analysis of the post-transcriptional regulator RsmA reveals a novel RNA-binding site.
Journal of molecular biology - 3 Feb 2006
Heeb Stephan, Kuehne Sarah A, Bycroft Mark, Crivii Sorana, Allen Mark D, Haas Dieter, Cámara Miguel, Williams Paul
Abstract excerpt
The RsmA family of RNA-binding proteins are global post-transcriptional regulators that mediate extensive changes in gene expression in bacteria. They bind to, and affect the translation rate of target mRNAs, a function that is further modulated by one or more, small, untranslated competitive regulatory RNAs. To gain new insights into the nature of this protein/RNA interaction, we used X-ray crystallography to...
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