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Article

Heterologous Expression of Der Homologs in an Escherichia coli der Mutant and Their Functional Complementation.

Journal of bacteriology - 1 Sept 2016

Choi Eunsil, Kang Nalae, Jeon Young, Pai Hyun-Sook, Kim Sung-Gun, Hwang Jihwan

Abstract excerpt

UNLABELLED: The unique Escherichia coli GTPase Der (double Era-like GTPase), which contains tandemly repeated GTP-binding domains, has been shown to play an essential role in 50S ribosomal subunit biogenesis. The depletion of Der results in the accumulation of precursors of 50S ribosomal subunits that are structurally unstable at low Mg(2+) concentrations. Der homologs are ubiquitously found in eubacteria....

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Identifiers

PMID: 27297882
DOI: 10.1128/JB.00384-16
PMCID: PMC4984549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Heterologous Expression of Der Homologs in an Escherichia coli der Mutant and Their Functional Complementation.PMID 27297882Read ↗

Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain.Semantic proximity Read ↗

RelA functionally suppresses the growth defect caused by a mutation in the G domain of the essential Der protein.Semantic proximity Read ↗

Expression phenotypes suggest that Der participates in a specific, high affinity interaction with membranes.Semantic proximity Read ↗

Crippling the essential GTPase Der causes dependence on ribosomal protein L9.Semantic proximity Read ↗

The widely conserved Era G-protein contains an RNA-binding domain required for Era function in vivo.Semantic proximity Read ↗

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Conserved Function of Drg GTPases in Promoting Protein Synthesis in Stalled RibosomesSemantic proximity Read ↗

Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity.Semantic proximity Read ↗

Deletion of the putative effector region of Era, an essential GTP-binding protein in Escherichia coli, causes a dominant-negative phenotype.Semantic proximity Read ↗

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The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties.Semantic proximity Read ↗

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