Article
Histone H4 Acetylation is Essential to Proceed from a Histone- to a Protamine-based Chromatin Structure in Spermatid Nuclei ofDrosophila melanogaster
1 Jan 2010
Abstract excerpt
In humans, other mammals, and also in Drosophila, the paternal genome in the sperm is highly condensed and organized mainly in a protamine-based chromatin structure. However, the timing and mechanism of the switch from a histone- to the protamine-based chromatin configuration is still poorly understood. We therefore established Drosophila in vitro cultures of cysts with 64 synchronously developing spermatids...
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