Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians.

doi:10.1111/j.1464-5491.2006.01834.x

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Article

Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians.

Diabetic medicine : a journal of the British Diabetic Association - 1 Apr 2006

Wolford J K, Yeatts K A, Red Eagle A R, Nelson R G, Knowler W C, Hanson R L

Abstract excerpt

AIMS: The aldose reductase gene (AKR1B1) is a strong candidate for diabetic nephropathy, and the T allele at rs759853 and the Z-2 allele at an [AC]n microsatellite are associated with diabetic kidney disease in some populations. As AKR1B1 is located on 7q35, where we have previously reported linkage to diabetic nephropathy in Pima Indians, this study examined the association of AKR1B1 variants with diabetic...

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PMID: 16620264
DOI: 10.1111/j.1464-5491.2006.01834.x

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