Article
Single amino acid substitution (58Pro-->Ser) in HTLV-I tax results in loss of ras cooperative focus formation in rat embryo fibroblasts.
Virology - 1 May 1994
Matsumoto K, Akashi K, Shibata H, Yutsudo M, Hakura A
Abstract excerpt
Two tax genes cloned from a healthy HTLV-I carrier in whom the viral genome is clonally integrated into peripheral CD4+CD8+ cells showed a considerable difference in ras cooperative focus forming ability in rat embryo fibroblasts (REF). Sequence analysis revealed differences in two codons of the...
Topics
- Animals
- Cell Transformation, Viral
- Cloning, Molecular
- Fibroblasts
- Gene Products, tax
- Genes, ras
- HTLV-I Infections
- Human T-lymphotropic virus 1
- Humans
- Mutation
- Proline
- Rats
- T-Lymphocyte Subsets
- Transcriptional Activation
- Viral Plaque Assay
- Virus Integration