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Article

Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.

Human molecular genetics - 15 May 2010

Reynolds Chandra A, Hong Mun-Gwan, Eriksson Ulrika K, Blennow Kaj, Wiklund Fredrik, Johansson Boo, Malmberg Bo, Berg Stig, Alexeyenko Andrey, Grönberg Henrik, Gatz Margaret, Pedersen Nancy L, Prince Jonathan A

Abstract excerpt

We conducted dense linkage disequilibrium (LD) mapping of a series of 25 genes putatively involved in lipid metabolism in 1567 dementia cases [including 1270 with Alzheimer disease (AD)] and 2203 Swedish controls. Across a total of 448 tested genetic markers, the strongest evidence of association...

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Source

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Identifiers

PMID: 20167577
DOI: 10.1093/hmg/ddq079
PMCID: PMC2860895

Genes

ATPAF2
ABCA1
APOE
CELSR2
GALNT2
GCKR
MLXIPL
PCSK9
PSRC1
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20167577-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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