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Article

Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex.

Cell reports - 13 Feb 2018

Denaxa Myrto, Neves Guilherme, Rabinowitz Adam, Kemlo Sarah, Liodis Petros, Burrone Juan, Pachnis Vassilis

Abstract excerpt

Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors, and their final...

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Identifiers

PMID: 29444425
DOI: 10.1016/j.celrep.2018.01.064
PMCID: PMC6230259

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