Article
Genetic and neuroradiological heterogeneity of double cortex syndrome.
Annals of neurology - 1 Feb 2000
Gleeson J G, Luo R F, Grant P E, Guerrini R, Huttenlocher P R, Berg M J, Ricci S, Cusmai R, Wheless J W, Berkovic S, Scheffer I, Dobyns W B, Walsh C A
Abstract excerpt
Mutations in the X-linked doublecortin gene appear in many sporadic cases of double cortex (DC; also known as subcortical band heterotopia), a neuronal migration disorder causing epilepsy and mental retardation. The purpose of this study was to examine why a significant percentage of sporadic DC patients had been found not to harbor doublecortin mutations and to determine whether clinical features or magnetic...
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