Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b.

The Journal of biological chemistry - 20 Jun 2003

Woelfle Joachim, Billiard Julia, Rotwein Peter

Abstract excerpt

Many of the effects of growth hormone (GH) are mediated by insulin-like growth factor-I (IGF-I), a secreted peptide whose gene transcription is induced by GH by unknown mechanisms. Recent studies in mice have implicated Stat5b as part of a GH-regulated somatic growth pathway, because mice lacking this transcription factor show diminished growth rates and a decline in serum IGF-I levels. To test the role of Stat5b...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Genetic Vectors
Share to Growth Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Milk Proteins

Share to Rats, Sprague-Dawley

Share to STAT5 Transcription Factor

Share to Trans-Activators

Source

Identifiers

PMID: 12682066
DOI: 10.1074/jbc.M301362200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b.PMID 12682066Read ↗

In vivo regulation of growth hormone-stimulated gene transcription by STAT5bSemantic proximity Read ↗

Mechanisms of Growth Hormone (GH) ActionSemantic proximity Read ↗

Characterization of Distinct Stat5b Binding Sites That Mediate Growth Hormone-stimulated IGF-I Gene TranscriptionSemantic proximity Read ↗

In Vivo Transcript Profiling and Phylogenetic Analysis Identifies Suppressor of Cytokine Signaling 2 as a Direct Signal Transducer and Activator of Transcription 5b Target in LiverSemantic proximity Read ↗

Dispersed Chromosomal Stat5b-binding Elements Mediate Growth Hormone-activated Insulin-like Growth Factor-I Gene TranscriptionSemantic proximity Read ↗

Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding SitesSemantic proximity Read ↗

Identification of a Distal STAT5-binding DNA Region That May Mediate Growth Hormone Regulation of Insulin-like Growth Factor-I Gene ExpressionSemantic proximity Read ↗

Insulin-Like Growth Factor Binding Protein-5 in Physiology and DiseaseSemantic proximity Read ↗

STAT5b deficiency: lessons from STAT5b gene mutations.Semantic proximity Read ↗

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expressionSemantic proximity Read ↗

IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo.Semantic proximity Read ↗

Minireview: Mechanisms of Growth Hormone-Mediated Gene RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.