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Article

Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity

28 Jun 2012

Abstract excerpt

Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN). We found that activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation was blocked by DEN-encoded NS2B3 through a protease-dependent mechanism. The key adaptor protein in type I interferon pathway, human mediator of IRF3 activation...

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PMID: 22761576
DOI: 10.1371/journal.ppat.1002780

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