Article
Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
24 Jan 2019
Abstract excerpt
Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As mutations in STAT5B , but not STAT5A , have been frequently described in hematopoietic tumors, we used BCR/ABL as model systems to investigate the contribution of STAT5A or STAT5B for leukemogenesis. The...
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