Article
Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2011
Verhoeven Manon C, Haase Christa, Christoffels Vincent M, Weidinger Gilbert, Bakkers Jeroen
Abstract excerpt
In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/β-catenin...
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