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Article

E3 ligase Nedd4 promotes axon branching by downregulating PTEN.

Neuron - 11 Feb 2010

Drinjakovic Jovana, Jung Hosung, Campbell Douglas S, Strochlic Laure, Dwivedy Asha, Holt Christine E

Abstract excerpt

Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either which specific UPS components are involved or UPS targets in neurons. We report that inhibiting the UPS in developing Xenopus retinal gan...

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Source

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Identifiers

PMID: 20159448
DOI: 10.1016/j.neuron.2010.01.017
PMCID: PMC2862300

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159448-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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