Article
Association of polymorphisms in complement component 3 with age-related macular degeneration in an Iranian population.
Ophthalmic genetics - 1 Jan 2000
Bonyadi Mortaza, Mohammadian Tahereh, Jabbarpoor Bonyadi Mohammad Hossein, Fotouhi Nikou, Soheilian Masoud, Javadzadeh Alireza, Moein Hamidreza, Yaseri Mehdi
Abstract excerpt
BACKGROUND: Age related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population. Inflammatory mediators play an important role in AMD pathogenesis and immune-related gene polymorphisms are shown to increase the risk. Complement system is an important mediator of the immunity system and several genes encoding proteins involved in this system are associated with...
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