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Article

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.

Aging - 15 Jan 2009

McCord Ronald A, Michishita Eriko, Hong Tao, Berber Elisabeth, Boxer Lisa D, Kusumoto Rika, Guan Shenheng, Shi Xiaobing, Gozani Or, Burlingame Alma L, Bohr Vilhelm A, Chua Katrin F

Abstract excerpt

The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have analogous functions, because SIRT6-deficiency leads to shortened life span and an aging-like degenerative phenotype in mice...

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Identifiers

PMID: 20157594
DOI: 10.18632/aging.100011
PMCID: PMC2815768

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20157594-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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