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Article

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells

4 Feb 2009

Abstract excerpt

Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, reactive oxygen species, and genome instability. However, the contribution of telomere-associated versus telomere-independent endogenous DNA lesions to this damage has never been examined. In this study, we characterized the relative amounts of these two types...

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PMID: 20157510
DOI: 10.18632/aging.100019

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