Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Damage Induces Alternative Lengthening of Telomeres (ALT)–Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNA

25 Jul 2007

Abstract excerpt

The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of their telomeres by using a recombination-mediated alternative lengthening of telomeres (ALT)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17652140
DOI: 10.1158/0008-5472.can-07-1556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Damage Induces Alternative Lengthening of Telomeres (ALT)–Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNAPMID 17652140Read ↗

Alternative lengthening of telomeres in mammalian cells.Semantic proximity Read ↗

Alternative lengthening of telomeres: remodeling the telomere architectureSemantic proximity Read ↗

Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.Semantic proximity Read ↗

ALTercations at telomeres: stress, recombination and extrachromosomal affairsSemantic proximity Read ↗

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeresSemantic proximity Read ↗

Alternative lengthening of telomeres: mechanism and the pathogenesis of cancerSemantic proximity Read ↗

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooksSemantic proximity Read ↗

Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression.Semantic proximity Read ↗

Telomere length maintenance--an ALTernative mechanism.Semantic proximity Read ↗

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.Semantic proximity Read ↗

Telomerase-Independent Telomere Length Maintenance in the Absence of Alternative Lengthening of Telomeres–Associated Promyelocytic Leukemia BodiesSemantic proximity Read ↗

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.