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Article

Telomere Loss as a Mechanism for Chromosome Instability in Human Cancer

19 May 2010

Abstract excerpt

Cancer cells commonly have a high rate of telomere loss, even when expressing telomerase, contributing to chromosome instability and tumor cell progression. This review addresses the hypothesis that this high rate of telomere loss results from a combination of four factors. The first factor is an increase in the frequency of double-strand breaks (DSB) at fragile sites in cancer cells due to replication stress....

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PMID: 20484032
DOI: 10.1158/0008-5472.can-09-4357

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