Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A doubly robust test for gene-environment interaction in family-based studies of affected offspring.

Biostatistics (Oxford, England) - 1 Apr 2010

Moerkerke Beatrijs, Vansteelandt Stijn, Lange Christoph

Abstract excerpt

We develop a locally efficient test for (multiplicative) gene-environment interaction in family studies that collect genotypic information and environmental exposures for affected offspring along with genotypic information for their parents or relatives. The proposed test does not require modeling the effects of environmental exposures and is doubly robust in the sense of being valid if either a model for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Macroglobulins
Share to Apolipoproteins E
Share to Biometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Confounding Factors, Epidemiologic

Share to Environment

Share to Family

Share to Models, Statistical

Share to Molecular Epidemiology

Source

Open in PubMed Open full text

Identifiers

PMID: 20154305
DOI: 10.1093/biostatistics/kxp061
PMCID: PMC2830581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A doubly robust test for gene-environment interaction in family-based studies of affected offspring.PMID 20154305Read ↗

Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysis.Semantic proximity Read ↗

Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects.Semantic proximity Read ↗

Family-based gene-by-environment interaction studies: revelations and remedies.Semantic proximity Read ↗

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.Semantic proximity Read ↗

Robust discovery of genetic associations incorporating gene-environment interaction and independence.Semantic proximity Read ↗

Simultaneously testing for marginal genetic association and gene-environment interaction.Semantic proximity Read ↗

Exploiting gene-environment interaction to detect genetic associations.Semantic proximity Read ↗

A sibling-augmented case-only approach for assessing multiplicative gene-environment interactions.Semantic proximity Read ↗

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variablesSemantic proximity Read ↗

Testing gene-gene interactions in the case-parents design.Semantic proximity Read ↗

The family based association test method: strategies for studying general genotype--phenotype associations.Semantic proximity Read ↗

A Sparse Additive Model for High-Dimensional Interactions with an Exposure VariableSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.