Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner.

Circulation research - 2 Apr 2010

Chan Jeffrey, Prado-Lourenco Leonel, Khachigian Levon M, Bennett Martin R, Di Bartolo Belinda A, Kavurma Mary M

Abstract excerpt

RATIONALE: TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is well reported as an inducer of apoptosis in tumor models; however, its role and function in vivo in atherosclerosis and vascular injury has not been established. OBJECTIVE: We sought to study the function of TRAIL in ca...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Femoral Artery
Share to Fibroblast Growth Factor 2
Share to Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Sp1 Transcription Factor

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Tunica Intima

Source

Identifiers

PMID: 20150555
DOI: 10.1161/CIRCRESAHA.109.206029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20150555-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner.PMID 20150555Read ↗

Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO₂.Semantic proximity Read ↗

Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice.Semantic proximity Read ↗

C1q/TNF-related protein 1 prevents neointimal formation after arterial injury.Semantic proximity Read ↗

Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury.Semantic proximity Read ↗

FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).Semantic proximity Read ↗

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms.Semantic proximity Read ↗

Phenotypic alterations in human saphenous vein culture induced by tumor necrosis factor-alpha and lipoproteins: a preliminary development of an initial atherosclerotic plaque model.Semantic proximity Read ↗

FOXO3a in vascular smooth muscle cell apoptosisSemantic proximity Read ↗

Tumor necrosis factor superfamily molecules in acute coronary syndromesSemantic proximity Read ↗

Inhibitor of apoptosis protein survivin regulates vascular injury.Semantic proximity Read ↗

TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular DiseasesSemantic proximity Read ↗

Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.