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Article

Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement.

Circulation research - 28 Aug 2009

Tan Nicole Y, Li Jian-Mei, Stocker Roland, Khachigian Levon M

Abstract excerpt

RATIONALE: Fas ligand (FasL)-mediated smooth muscle cell (SMC) apoptosis within the vulnerable plaque may lead to plaque instability and rupture, events that underlie myocardial infarction and stroke. OBJECTIVE: The molecular mechanisms underlying FasL transcription and FasL-dependent SMC apoptosis were investigated in this study in vitro and in vivo. METHODS AND RESULTS: We demonstrate that GATA-6, the...

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Source

Identifiers

PMID: 19628789
DOI: 10.1161/CIRCRESAHA.109.203323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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