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Article

Mutation frequency in antibiotic-resistant and -susceptible isolates of Streptococcus pneumoniae.

International journal of antimicrobial agents - 1 Apr 2010

Henderson-Begg Stephanie K, Sheppard Carmen L, George Robert C, Livermore David M, Hall Lucinda M C

Abstract excerpt

Development of multiple antibiotic resistance in Streptococcus pneumoniae typically involves either mutation or transformation at several well-separated chromosomal loci. We postulated that this series of genetic events would be more likely to occur in organisms with deficient DNA repair mechanisms. Investigation of 27 antibiotic-resistant or -susceptible clinical isolates of S. pneumoniae revealed a broad range...

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PMID: 20149603
DOI: 10.1016/j.ijantimicag.2009.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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