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Article

Evolution in fast forward: a potential role for mutators in accelerating Staphylococcus aureus pathoadaptation.

Journal of bacteriology - 1 Feb 2013

Canfield Gregory S, Schwingel Johanna M, Foley Matthew H, Vore Kelly L, Boonanantanasarn Kanitsak, Gill Ann L, Sutton Mark D, Gill Steven R

Abstract excerpt

Pathogen evolution and subsequent phenotypic heterogeneity during chronic infection are proposed to enhance Staphylococcus aureus survival during human infection. We tested this theory by genetically and phenotypically characterizing strains with mutations constructed in the mismatch repair (MMR) and oxidized guanine (GO) system, termed mutators, which exhibit increased spontaneous-mutation frequencies. Analysis...

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Identifiers

PMID: 23204459
DOI: 10.1128/JB.00733-12
PMCID: PMC3554003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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