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Article

Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.

Antimicrobial agents and chemotherapy - 1 Sept 2007

Gould Carolyn V, Sniegowski Paul D, Shchepetov Mikhail, Metlay Joshua P, Weiser Jeffrey N

Abstract excerpt

The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selection for levofloxacin-resistant mutants of strain D39, each with point mutations in both gyrA and parC or parE, was not associated with a significant change in the mutation rate. Two of eight clinical isolates resistant...

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Identifiers

PMID: 17664329
DOI: 10.1128/AAC.00336-07
PMCID: PMC2043225

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Source receipt: pubmed, retrieved 7 Sept 2026.

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