Article
Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.
Antimicrobial agents and chemotherapy - 1 Sept 2007
Gould Carolyn V, Sniegowski Paul D, Shchepetov Mikhail, Metlay Joshua P, Weiser Jeffrey N
Abstract excerpt
The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selection for levofloxacin-resistant mutants of strain D39, each with point mutations in both gyrA and parC or parE, was not associated with a significant change in the mutation rate. Two of eight clinical isolates resistant...
Topics
- Anti-Bacterial Agents
- DNA Repair
- DNA, Bacterial
- Drug Resistance, Bacterial
- Fluoroquinolones
- Humans
- Molecular Sequence Data
- Mutation
- Mutation, Missense
- Phenotype
- Pneumococcal Infections