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Article

Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.

European journal of clinical pharmacology - 1 May 2010

Ghotbi Roza, Mannheimer Buster, Aklillu Eleni, Suda Akira, Bertilsson Leif, Eliasson Erik, Osby Urban

Abstract excerpt

PURPOSE: The impact of the UGT1A4, CYP1A2, and MDR1 genetic variants on olanzapine plasma levels, in relation to those of other individual factors, such as gender, smoking status, body weight, and age, was investigated in patients with schizophrenia. METHODS: A total of 121 patients were recruite...

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Source

Identifiers

PMID: 20143052
DOI: 10.1007/s00228-009-0783-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20143052-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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