Article
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia.
Molecular psychiatry - 1 Jul 2000
Basile V S, Ozdemir V, Masellis M, Walker M L, Meltzer H Y, Lieberman J A, Potkin S G, Alva G, Kalow W, Macciardi F M, Kennedy J L
Abstract excerpt
Tardive dyskinesia (TD) is a common and potentially irreversible side effect associated with long-term treatment with typical antipsychotics. Approximately, 80% or more of patients with schizophrenia are smokers. Smoking is a potent inducer of the CYP1A2 enzyme, and is known to cause a significan...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.