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Article

Functional determinants of lysophospholipid- and voltage-dependent regulation of TRPC5 channel.

Cellular and molecular life sciences : CMLS - 29 Aug 2024

Ptakova Alexandra, Zimova Lucie, Barvik Ivan, Bon Robin S, Vlachova Viktorie

Abstract excerpt

Lysophosphatidylcholine (LPC) is a bioactive lipid present at high concentrations in inflamed and injured tissues where it contributes to the initiation and maintenance of pain. One of its important molecular effectors is the transient receptor potential canonical 5 (TRPC5), but the explicit mechanism of the activation is unknown. Using electrophysiology, mutagenesis and molecular dynamics simulations, we show...

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Identifiers

PMID: 39210039
DOI: 10.1007/s00018-024-05417-7
PMCID: PMC11362415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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