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Article

Osteoblast role in osteoarthritis pathogenesis.

Journal of cellular physiology - 1 Nov 2017

Maruotti Nicola, Corrado Addolorata, Cantatore Francesco P

Abstract excerpt

Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregulation of osteoblast...

Topics

Animals
Bone Remodeling
Disease Progression
Gene Expression Regulation
Humans
Joints
Osteoarthritis
Osteoblasts
Phenotype
Signal Transduction

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Identifiers

PMID: 28425564
DOI: 10.1002/jcp.25969
PMCID: PMC5575507

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