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Article

Concentration-dependent effects of leptin on osteoarthritis-associated changes in phenotype of human chondrocytes.

Connective tissue research - 1 Sept 2023

Primrose Julia Gb, Jain Lekha, Bolam Scott M, Monk A Paul, Munro Jacob T, Dalbeth Nicola, Poulsen Raewyn C

Abstract excerpt

Metabolic syndrome is a risk factor for osteoarthritis. Elevated leptin levels have been implicated as a potential cause of this association. Previous studies have shown that supra-physiological leptin concentrations can induce osteoarthritis-like changes in chondrocyte phenotype. Here, we tested the effects of leptin in the concentration range found in synovial fluid on chondrocyte phenotype. Chondrocytes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37171229
DOI: 10.1080/03008207.2023.2214249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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