Article
Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.
Arthritis research & therapy - 30 Jun 2017
Abed Élie, Delalandre Aline, Lajeunesse Daniel
Abstract excerpt
BACKGROUND: Osteoarthritis (OA) is a complex disease, which affects multiple tissues, namely the subchondral bone, articular cartilage and synovial membrane. Alterations of the subchondral bone include an increased, yet under mineralized osteoid matrix, abnormal osteoblast cell phenotype including elevated alkaline phosphatase (ALP) activity, increased release of osteocalcin (OC) and transforming growth factor...
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