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Article

Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.

The Journal of biological chemistry - 11 Feb 2005

Chen Jin-Ran, Plotkin Lilian I, Aguirre José Ignacio, Han Li, Jilka Robert L, Kousteni Stavroula, Bellido Teresita, Manolagas Stavros C

Abstract excerpt

Sex steroids exert anti-apoptotic effects on osteoblasts/osteocytes but exert pro-apoptotic effects on osteoclasts, in both cases requiring activation of the extracellular signal-regulated kinases (ERKs). To explain the mechanistic basis of this divergence, we searched for differences in the kinetics of phosphorylation and/or in the subcellular localization of ERKs in response to 17beta-estradiol in the two cell...

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Identifiers

PMID: 15557324
DOI: 10.1074/jbc.M411530200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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