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Article

The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.

AIDS (London, England) - 13 Mar 2010

Knops Elena, Kemper Ina, Schülter Eugen, Pfister Herbert, Kaiser Rolf, Verheyen Jens

Abstract excerpt

Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occ...

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Source

Identifiers

PMID: 20139751
DOI: 10.1097/QAD.0b013e328336784d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20139751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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