Article
Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.
Antimicrobial agents and chemotherapy - 1 Nov 2010
Young Thomas P, Parkin Neil T, Stawiski Eric, Pilot-Matias Tami, Trinh Roger, Kempf Dale J, Norton Michael
Abstract excerpt
Patterns of HIV-1 protease inhibitor (PI) resistance-associated mutations (RAMs) and effects on PI susceptibility associated with the L76V mutation were studied in a large database. Of 20,501 sequences with ≥1 PI RAM, 3.2% contained L76V; L76V was alone in 0.04%. Common partner mutations included M46I, I54V, V82A, I84V, and L90M. L76V was associated with a 2- to 6-fold decrease in susceptibility to lopinavir,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.