Article
Viral dynamics and mutations in the pol gene during primary HIV-1 infection.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Cenci A, Bertoli A, Tambussi G, Menzo S, Clementi M, Lazzarin A, Capiluppi B, Ciuffreda D, Forbici F, Aquaro S, Marcuccilli F, Caliò R, Perno C F
Abstract excerpt
The understanding of viral dynamics and appearance of mutations during primary infection could be useful for the design of an efficient therapy. For this reason a cohort of samples from naive primary patients was examined. The results pointed out that only a few secondary mutations in protease gene (having no effect on resistance) were found, while a single mutation conferring resistance to non-nucleosides...
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