Article
Blockade of the Ras-extracellular signal-regulated kinase 1/2 pathway is involved in smooth muscle 22 alpha-mediated suppression of vascular smooth muscle cell proliferation and neointima hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2010
Dong Li-Hua, Wen Jin-Kun, Liu George, McNutt Michael A, Miao Sui-Bing, Gao Rui, Zheng Bin, Zhang Hailin, Han Mei
Abstract excerpt
OBJECTIVE: Vascular smooth muscle cells (VSMCs) can switch between differentiated and dedifferentiated phenotypes, and this phenotype switch is believed to be essential for repair of vascular injury. We studied the inhibitory effect of smooth muscle 22 alpha (SM22 alpha) on VSMC proliferation in vitro and in vivo and explored the potential molecular mechanisms of this effect. METHODS AND RESULTS: By using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.