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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay

4 Apr 2016

Abstract excerpt

The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can serve as cells of origin for prostate cancer. Using a human prostate regeneration and transformation assay, our group previously demonstrated that basal cells can serve as efficient targets for transformation. Recently, a subpopulation of multipotent human...

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PMID: 27044116
DOI: 10.1073/pnas.1603645113

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