Article
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.
Cell reports - 15 Dec 2015
Agarwal Supreet, Hynes Paul G, Tillman Heather S, Lake Ross, Abou-Kheir Wassim G, Fang Lei, Casey Orla M, Ameri Amir H, Martin Philip L, Yin Juan Juan, Iaquinta Phillip J, Karthaus Wouter R, Clevers Hans C, Sawyers Charles L, Kelly Kathleen
Abstract excerpt
Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that two classes of luminal progenitors exist within a tumor. Not only did tumors contain previously described multipotent progenitors, but also a major population of committed...
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