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Human Epithelial Basal Cells Are Cells of Origin of Prostate Cancer, Independent of CD133 Status

3 Apr 2012

Abstract excerpt

Normal prostatic epithelium is composed of basal and luminal cells. Prostate cancer can be initiated in both benign basal and luminal stem cells, but because basal cell markers are not expressed in patient tumors, the former result was unexpected. Since the cells of origin of prostate cancer are important therapeutic targets, we sought to provide further proof that basal stem cells have tumorigenic potential....

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PMID: 22593016
DOI: 10.1002/stem.1094

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