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Article

Securinine induces p73‐dependent apoptosis preferentially in p53‐deficient colon cancer cells

4 Feb 2010

Abstract excerpt

The identification of agents that preferentially kill cancer cells while protecting normal cells offers the potential to overcome toxicities found in many existing chemotherapeutic agents. Because p53 is frequently inactivated in cancer, agents that preferentially kill p53-null cells and protect wild-type p53-expressing cells are highly desirable chemotherapeutic agents. By using pairs of isogenic colon cancer...

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PMID: 20133503
DOI: 10.1096/fj.09-148999

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