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Article

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.

PloS one - 1 Jan 2015

Mrozek-Wilczkiewicz Anna, Spaczynska Ewelina, Malarz Katarzyna, Cieslik Wioleta, Rams-Baron Marzena, Kryštof Vladimír, Musiol Robert

Abstract excerpt

A group of styrylquinolines were synthesized and tested for their anti-proliferative activity. Anti-proliferative activity was evaluated against the human colon carcinoma cell lines that had a normal expression of the p53 protein (HCT116 p53+/+) and mutants with a disabled TP53 gene (HCT116 p53-/-) and against the GM 07492 normal human fibroblast cell line. A SAR study revealed the importance of Cl and OH as...

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Identifiers

PMID: 26599982
DOI: 10.1371/journal.pone.0142678
PMCID: PMC4657899

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