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Article

An Epigenetic Modifier Results in Improved <i>In Vitro</i> Blastocyst Production after Somatic Cell Nuclear Transfer

1 Sept 2007

Abstract excerpt

The present study was designed to examine the effect of trichostatin A (TSA), an inhibitor of histone deacetylase, on development of porcine cloned embryos. Our results showed that treatment of cloned embryos derived from sow oocytes with 50 nM TSA for up to 24 h after the onset of activation could significantly improve blastocyst yield compared to the control (46.4+/-4.6% vs 17.7+/-4.9% for treated and untreated...

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Identifiers

PMID: 17907946
DOI: 10.1089/clo.2006.0090

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Related research

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An Epigenetic Modifier Results in Improved <i>In Vitro</i> Blastocyst Production after Somatic Cell Nuclear TransferPMID 17907946Read ↗

Histone Deacetylase Inhibitors Improve <i>In Vitro</i> and <i>In Vivo</i> Developmental Competence of Somatic Cell Nuclear Transfer Porcine EmbryosSemantic proximity Read ↗

Acetylation Level of Histone H3 in Early Embryonic Stages Affects Subsequent Development of Miniature Pig Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Trichostatin A Improves Histone Acetylation in Bovine Somatic Cell Nuclear Transfer Early EmbryosSemantic proximity Read ↗

Comparison between the Effects of Valproic Acid and Trichostatin A on the <i>In Vitro</i> Development, Blastocyst Quality, and Full-Term Development of Mouse Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Simultaneous Inhibition of Histone Deacetylases and RNA Synthesis Enables Totipotency Reprogramming in Pig SCNT EmbryosSemantic proximity Read ↗

Effects of Histone Deacetylase Inhibitor Oxamflatin on <i>In Vitro</i> Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Trichostatin A Improved Epigenetic Modifications of Transfected Cells but did not Improve Subsequent Cloned Embryo DevelopmentSemantic proximity Read ↗

Trichostatin A and nuclear reprogramming of cloned rabbit embryos1Semantic proximity Read ↗

Oxamflatin Treatment Enhances Cloned Porcine Embryo Development and Nuclear Reprogramming <sup/>Semantic proximity Read ↗

Oxamflatin Improves Developmental Competence of Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errorsSemantic proximity Read ↗

Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transferSemantic proximity Read ↗

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