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Hepatitis B Virus Subviral Envelope Particle Morphogenesis and Intracellular Trafficking

3 Feb 2007

Abstract excerpt

Hepatitis B virus (HBV) is unusual in that its surface proteins (small [S], medium, and large [L]) are not only incorporated into the virion envelope but they also bud into empty subviral particles in great excess over virions. The morphogenesis of these subviral envelope particles remains unclear, but the S protein is essential and sufficient for budding. We show here that, in contrast to the presumed model, the...

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PMID: 17267490
DOI: 10.1128/jvi.02741-06

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